The setting will change if you use Adaptive sync. *Refresh rate – highest available to use the maximum potential of your monitor. If you are on a laptop or on a PC that has thermal issues and are willing to sacrifice performance choose a different value that will help with power saving. *Power management mode is set to Prefer maximum performance to allow the GPU to boost to the highest clock and keep it that way for best latency and performance. If your games do not use more than 85% of your GPU leave Low Latency Mode off. Having this on Ultra might affect your FPS a bit since your CPU has to work harder. * Low Latency Mode you can keep on On or Ultra as it helps with limiting queued frames, therefore, lowering input lag in games that do not use Nvidia Reflex technology.